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Showing posts from 2022

RT @CancerInNorwich: 📢 Join us for our next virtual seminar, where Qi Wang from @UeaMed will be talking about "Interaction between BITC and Sorafenib and their therapeutic potential on breast cancer treatment". All are welcome to join via the MS Teams link: https://t.co/FW2NaxhG9G #CancerInNorwich https://t.co/UHnXTaDDqt


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This is a really interesting article about Maxwell and scientific publishing. https://t.co/NeLAnXgf7H


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RT @MEAssociation: 1/2 ME Awareness Week 9th -15th May 2022. ME/CFS is estimated to affect around 0.2-0.4% (c.265,000 people in the UK) of the population - including children and adolescents. However, the number of people with ME/CFS may rise due to the Covid pandemic. https://t.co/qQLawH1FJq


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RT @DataCamp: Not sure about what different machine learning models do and when to use them? 🤔 Our handy cheat sheet has all the need-to-know advantages, disadvantages, and key use cases: https://t.co/i7zneHHOTZ #Data #MachineLearning #Cheatsheet #ML https://t.co/4OxlePsBrQ


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RT @George_Thompo: The final result is the Eaton ward, and the only one with a Lib Dem win. Caroline Ackroyd has retained the seat. The results were: Caroline Ackroyd (LD) 2,069 Peter Prinsley (L) 1,310 Jane Saunders (G) 336 John Ward (C) 560


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RT @alfie_stirling: New from @NEF today. Rising costs for essentials are hitting the poorest hardest. On average, costs are rising by £2,300/yr this year. But they are rising 9 times faster for the poorest half of families, compared to the top 5%, as a proportion of income. 🧵1/ https://t.co/cP8w5vJxf0


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RT @CancerInNorwich: We're still here in @TheForumNorwich - come along and speak with some of the cancer researchers in our network! #cancerinnorwich #cancerresearch https://t.co/9BMNtAw1n4


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RT @CancerInNorwich: We're all set up in @TheForumNorwich for the @UeaCitizenAcad Launch event! Come along to hear all about cancer screening and drug discovery #CancerInNorwich #cancerresearch https://t.co/23jeyL6wfF


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RT @CancerInNorwich: We're excited to be hosting a stall at the @UeaCitizenAcad launch event at @TheForumNorwich on Tuesday between 12-5pm. Come along to hear all things #cancerresearch from some of our researchers and get involved in activities based around our key research areas! #CancerInNorwich https://t.co/5BIEnWCwVB


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I can relate https://t.co/G5foHEhDAo


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RT @chngin_the_wrld: Today's #shoutout to #womenInSTEM goes to Rachel Hurst & @meader_emma for their paper w/ @johnwain6 & @danbrewer suggesting that urine #microbiomes are associated w/ #ProstateCancer. https://t.co/gQQGbBjvOU


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RT @CancerInNorwich: 📢Join us next Wednesday for our next virtual seminar with Prakit Kumar from @UeaMed, who will be talking about "Understanding Tumour Cell Interactions with Stromal Cells". All are welcome to join via the MS Teams link: https://t.co/FW2NaxhG9G #CancerInNorwich #CancerResearch https://t.co/jWGNuG0xO2


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Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups

 

New paper published today titled "Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups" in European Urology Oncology. 

Papers are coming like buses this week. Delighted that after nine years of work our paper looking at the link between bacteria and aggressive prostate cancer is out. This is exciting stuff.

https://doi.org/10.1016/j.euo.2022.03.006

We already know of some strong associations between infections and cancer. For example, the presence of Helicobacter pylori bacteria in the digestive tract can lead to stomach ulcers and is associated with stomach cancer, and some types of the HPV virus can cause cervical cancer. We wanted to find out whether bacteria could be linked to the way prostate cancer grows and spreads.

We analysed urine or tissue samples from more than 600 patients with or without prostate cancer. And we developed methods of finding the bacteria associated with aggressive prostate cancer. We found several types of bacteria associated with aggressive prostate cancer, some of which are new types of bacteria never found before. The set of bacteria found include Anaerococcus, Peptoniphilus, Porphyromonas, Fenollaria and Fusobacterium. All of these are anaerobic, which means they like to grow without oxygen present.



When any of these specific anaerobic bacteria were detected in the patient’s samples, it was linked to the presence of higher grades of prostate cancer and more rapid progression to aggressive disease. We also identified potential biological mechanisms of how these bacteria may be linked to cancer. Among the things we don’t yet know is how people pick up these bacteria, whether they are causing the cancer, or whether a poor immune response permits the growth of the bacteria. But we hope that our findings and future work could lead to new treatment options, that could slow or prevent aggressive prostate cancer from developing. Our work could also lay the foundations for new tests that use bacteria to predict the most effective treatment for each man’s cancer.


Amazing collaboration between Norwich Medical School UEA, Quadram Institute, the NNUH and others. It was funded by the by Prostate Cancer UK and The Bob Champion Cancer Trust.

Press Coverage:

RT @ProstateUK: 🔬 This is an exciting discovery that has the potential to truly revolutionise treatment for men. https://t.co/GsWJH6HgCg


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RT @UEAResearch: Our researchers @UeaMed have found a link between bacteria & aggressive prostate cancer 👩‍🔬🔬 We hope it will pave the way for new treatments #ThinkingWithoutBorders 👉 https://t.co/foSwzeBAK3 @ProstateUK @BobChampion1981 @TheQuadram @EarlhamInst @NNUH #prostatecancer #cancer https://t.co/aOFsfYgb9b


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RT @BBCNews: Urine bugs may be a sign of aggressive prostate cancer https://t.co/wQPSEYdvzs


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I'm delighted to announce a new paper out from our group based on data from the @MovemberUK GAP1 Urine biomarker consortium: "A Model to Detect Significant Prostate Cancer Integrating Urinary Peptide and Extracellular Vesicle RNA Data". https://t.co/8WfRKbYSjE https://t.co/NDReK5Nrrm


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RT @mikelove: Got an RNA-seq dataset with 50, 100, 200+ samples? Plug it into a differential expression tool and hope for the best? No! You need to consider QC, EDA, and modeling technical variation, or else risk generating spurious results. A thread on papers, methods, and best practices: https://t.co/p7Zn61QjHw


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RT @WvSchaik: This does not pertain to all current ERC grant holders but to those that have been awarded an ERC since late 2021, I believe. Not sure what this means for future ERC funding opportunities for researchers at UK unis (probably eligible but only if you then take grant to EU) https://t.co/O47EnP3JkJ


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RT @CancerInNorwich: We are excited to announce that our annual symposium has been rearranged and is taking place on the 9th June at @uniofeastanglia! Registration is open and we are still accepting submissions for late-breaking posters. Register here 👉https://t.co/1cd04Zdp0k #cancerinnorwich https://t.co/aPw4UPhPAo


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RT @cycling_podcast: A message from The Cycling Podcast. https://t.co/zZ3O0XaxTx https://t.co/fFjI87v51h


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RT @CancerInNorwich: Don't miss out on attending our next virtual seminar, which starts at 12pm today! 👇 https://t.co/EfGYA2VpyB


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RT @ONS: #COVID19 infections continued to increase across England, Wales and Scotland in the most recent week, but decreased in Northern Ireland. These high infection levels are driven by the Omicron BA.2 variant https://t.co/zjZZxROXBX https://t.co/C6Sjbi6IxM


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Huge numbers of COVID at the moment. https://t.co/XJ2yZIERWE


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RT @rcolvile: The latest housing affordability statistics are out and it is impossible to overstate what a horrifying, generationally traumatising shitshow they are. Here is the situation in 1997 vs 2021 https://t.co/QgYWaBlmUw https://t.co/Qf3whnAg7l


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RT @rcolvile: I have officially discovered the smallest particle in the universe, which consists of the amount of compassion shown by a three-year-old to a sick parent.


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RT @CancerInNorwich: 📢 Our next virtual seminar is taking place on the 30th March at 12pm. We will be joined by @FelixNaughton, to hear about "Supporting people to quit smoking via automated and highly tailored mobile phone support (mCessation)". All are welcome to join:https://t.co/FW2NaxhG9G #NCRN https://t.co/NQEjIBcxEg


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RT @vass_vassiliou: MY INAUGURAL LECTURE! Delighted to invite u 2 my lecture: Tue 15th March 18:30 UK @uniofeastanglia @UeaMed Hybrid- in person or join from this live-stream channel: https://t.co/UxVQccZKV9 I'll talk about #Cardiology , #whycmr & #covid (a bit!) #epeeps #cardioed #echofirst https://t.co/qH4dhvuUtD


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RT @dralynch: Two lectureships in Statistics (School of Maths and Stats) https://t.co/DxCke1ESvI and a Fellowship in Cancer Research (School of Medicine) https://t.co/uMb5zbCt2x currently advertised in St Andrews. Come and join us!


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RT @ONS: Today’s #COVID19 data shows increases in infections across all four nations of the UK ⬇ https://t.co/Ymspju7hEc https://t.co/bePyi0zVJE


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I can't believe it's been 20 years. The reason I wanted a DAB radio. Radio station of choice for about 18 years I think. https://t.co/j7GavtG29s


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In our final prostate cancer episode, we are back with Trevor Beckford who is taking us through his experience of prostate cancer diagnosis process in the UK. Prof Cooper also shares details of the next phase in his research . https://t.co/HU0pMMxLQw


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RT @CancerInNorwich: Today at 4pm- don't miss out on our next virtual seminar, all are welcome! 👇#CancerResearch #cancerinnorwich https://t.co/dyxhwDGbCK


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RT @CancerInNorwich: 📢Join us at 4pm on Wednesday 2nd March for our next seminar with Bogdan Luca from @Stanford, talking about: "Atlases of clinically-distinct cell states and cellular ecosystems in solid cancers and diffuse large B cell lymphoma". All are welcome to join: https://t.co/FW2NaxhG9G https://t.co/4nywEMaVSq


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RT @chrischirp: THREAD: I keep being asked when we can go "back to normal" or "like it was before". My personal thoughts: We've added a new disease to our population, more infectious and more severe than flu. The world pre 2020 no longer exists - we may want it to, but it just doesn't. 1/13


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RT @CancerInNorwich: Join is today at 2pm for our next virtual seminar! #CancerInNorwich #cancerresearch https://t.co/zp77XfFuar


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ONE DAY TO GO. Fully funded (for UK students) PhD studentship available applying machine learning to prostate cancer sequencing data. Join us in Norwich. Funded by @bigctweets and @UEAResearch. https://t.co/KSDLNWsvo6 https://t.co/1CMTkmsgAm


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RT @MutantBug: I am looking for a senior postdoc to lead on genome sequence analysis for the group. This is a key role and I will be looking to support long term through future funding applications/support to get an independent fellowship. RTs appreciated. https://t.co/om8AJvc0hj


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We are excited to have a fully funded (for UK) PhD studentship open for application. It's a project looking at sequencing data in prostate cancer to try and predict prostate cancer outcomes. Like the sound of that? Deadline 14/02/22 https://t.co/3gpDKYNMYT


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RT @uniofeastanglia: World-leading cancer geneticist, Professor Colin Cooper, has spent 20 years developing new diagnostic tests for prostate cancer. Discover more about Prof Cooper’s revolutionary work in our #PioneerPodcast prostate cancer special. 🎧 https://t.co/gLkqCNgMLJ #WorldCancerDay https://t.co/zPiHNoRm5t


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So according to some calculations if the USS pension fund achieves anything above a growth of CPI-0.23% it would lead to a surplus. This is getting silly. https://t.co/uGrLInBumy


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Peter Van Loo (@VanLooLab) is currently looking to recruit postdocs (3 year positions) in the Cancer Genomics and Evolution team at MD Anderson. Highly recommended. https://t.co/i9tWIrCFcw


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RT @EdConwaySky: 🚨NEW 🚨 Bank of England says UK households must brace themselves for the biggest annual fall in their standard of living since comparable records began three decades ago, as it: - Raises interest rates to 0.5% - Says inflation will surpass 7% - Slashes GDP forecast


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Looking for a PhD studentship? Do you like messing around with big data with a chance to improve people's lives? We've got a fully funded (for UK) position open for applications. Deadline 14/02/22. Contact me for more information. https://t.co/c5P4GwB5kw https://t.co/UdAgjjPQAs


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Tom Pidcock obliterates all competition to claim cyclocross world title https://t.co/V0pnjfRovE


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If you are looking for a PhD oppportunity applying machine learning techniques to optimally predict prostate cancer patient outcome, then we have the PhD for you. Come join a great supportive team at @UEAResearch at Norwich medical school. @UeaMed https://t.co/wgAfonOuXD https://t.co/o43VK928SR


from Twitter https://twitter.com/danbrewer

Fully funded PhD studentship available: "Applying machine learning to sequencing data to predict prostate cancer outcome". Deadline 14th Feb 2022. DM me to arrange a discussion. Funded by @bigctweets and @UEAResearch. https://t.co/y42aHILQ5y https://t.co/76s6DdOgPx


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RT @CarlaNotarobot: Linux isn't magic, it's sudo science.


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https://t.co/SJHvFvma83


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Competitive studentship available in our research group with the new Microbes, Microbiomes and Bioinformatics DTP in Norwich. HOW DO BACTERIA CONTRIBUTE TO AGGRESSIVE PROSTATE CANCER? – A JOINT LAB/BIOINFORMATICS PHD STUDENTSHIP. Deadline: 17th Jan 2022. https://t.co/BM6s069yGv https://t.co/cY2Mff9do2


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RT @wizbates: Chants of ‘my name is Boris’ and ‘this is a work event’ outside Downing Street as maybe a hundred bewigged Boris lookalikes jig around in the street. Utterly surreal https://t.co/3g6BCK1Hzl


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RT @Aiims1742: Doug Hanahan presents the third update to the iconic “Hallmarks of Cancer” in @CD_AACR this morning. New tenets added: phenotypic plasticity, epigenetic reprogramming, cellular senescence & to no one’s surprise, the microbiome. https://t.co/9fudt9DiDG #OpenAccess for all! https://t.co/1ZWKdJyPjG


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RT @ONS: The difference in median individual wealth between the South East (£236,000) and North East (£79,000) regions of England was £157,000 in April 2018 to March 2020. Explore our interactive map⬇️ https://t.co/Tpi6I3OU9S https://t.co/otU7pqzaBt


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RT @eliistender10: Tree hugger https://t.co/8faN2vRTXQ


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RT @chrischirp: 6% is huge (5.2% omicron, 0.7% Delta). That's over 3 million people in England... https://t.co/w7sKLSLZXW


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Happy new year everyone. Here's for a great 2022. https://t.co/gdpFZeWzp3


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