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Showing posts from March, 2020

RT @xkcdComic: Pathogen Resistance https://t.co/yE385vzG1f https://t.co/drYIKf3mm9 https://t.co/E2f4opvsUf


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A free book about COVID-19 for kids https://t.co/AQt5sjdnwj


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Help slow the spread of #COVID19 and identify at risk cases sooner by self-reporting your symptoms daily, even if you feel well 🙏🏼. Download the app https://t.co/chwr0CR30X


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Competition funding available for a PhD applying machine learning techniques to Next Generation Sequencing Big Data to improve the prediction of prostate cancer patient outcome. Join us. Stipend and UK/EU fees available. Closing date: 17/04/20 https://t.co/hCRNjxB0jC #phdtalk https://t.co/tKaBxFUR20


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"50% of the people who tested positive had no symptoms." Have I already had Covid-19? How would I know and what should I do? https://t.co/KtlJtz9Teq


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Lockdown!


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A novel stratification framework for predicting outcome in patients with prostate cancer

In all the madness I forgot to post about our latest publication published last Friday: A novel stratification framework for predicting outcome in patients with prostate cancer. Found in the British Journal of Cancer. 

We have discovered why some prostate cancers are more aggressive, spread to different parts of the body, and ultimately cause death.

Recently we developed a test to distinguish aggressive prostate cancers from less threatening forms of the disease, by applying some complex maths known as Latent Process Decomposition, that will help avoid sometimes-damaging unnecessary treatment. This aggressive form of prostate cancer is known as DESNT - which has the worst clinical outcomes for patients. In this study we carry on this work and studied gene expression levels in 1,785 prostate cancer tumour samples.

We show how the number of ‘aggressive’ cells in a tumour sample defines how quickly the disease will progress and spread. The more DESNT cells, the quicker the patient is likely to progress. We also revealed three new subtypes of prostate cancer that could be used to stratify patients for different treatments.

The research was funded by the Bob Champion Cancer Trust, the Masonic Charitable Foundation, the King Family, the Hargrave Foundation, and UEA, with support from Movember, Prostate Cancer UK, Callum Barton and from the Andy Ripley Memorial Fund.

https://doi.org/10.1038/s41416-020-0799-5

Kudos link: https://www.growkudos.com/publications/10.1038%25252Fs41416-020-0799-5/reader


RT @laoneill111: Latest science says you HAVE to stay home. 60% of infections now estimated from people with NO symptoms. 1 in 3 people have no symptoms but are infectious. It hasn’t hit yours lungs but it’s in your throat u cough or simply breath it out. Stay home. https://t.co/OsyEVJCn7z


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This is amazing, sports commentator had to improvise as no live sports. https://t.co/qVPBwfyCqc


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RT @UEAResearch: Researchers at #UEA have discovered why some #prostatecancers are more aggressive, spread to different parts of the body, and ultimately cause death https://t.co/wuH4c2lEpF @UeaMed @UEA_Computing @BobChampion1981 @Masonic_Charity @MovemberUK @ProstateUK #ThinkingWithoutBorders https://t.co/BWj74vDzFd


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In non-COVID-19 news, we've got our second paper of the month out today: A novel stratification framework for predicting outcome in patients with prostate cancer https://t.co/v7t9PKcnMm @UEAResearch @UeaMed https://t.co/xg65kj7LTJ


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RT @jtleek: If you are looking to read medical papers and understand the stats, check out our (free!) course on understanding data and statistics in the medical literature! https://t.co/g9x9USzjFY @LucyStats @elizabethmatsui


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Over simplified, but love this and the way it's presented. https://t.co/2Ka752TRnx


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RT @donmoyn: Real-time evidence of flattening the curve. Lodi had the first Covid-19 case in Italy, and implemented a shutdown on Feb 23. Bergamo waited until March 8. Look at the difference. Incredible research by @drjenndowd, @melindacmills & co-authors. https://t.co/JYf1F5GnYu https://t.co/iMVXBJ59Y6


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Competition funding available for a PhD applying machine learning techniques to Next Generation Sequencing Big Data to improve the prediction of prostate cancer patient outcome. Join us. Stipend and UK/EU fees available. Closing date: 17/04/20 https://t.co/hCRNjxB0jC #phdtalk https://t.co/l6YxzIFOKH


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RT @timberners_lee: It's not just a question of whether you get sick. More important is eliminating the chance that you end up being a one who spreads it. Act as though you have it already. Just in case you do. #coronavirus https://t.co/ZVCHCbuhfV


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UEA have announced that all teaching will be performed online from Monday. I don't have anything apart from an assessment for a couple of weeks but I feel sorry for my colleagues, who might have a tricky weekend. Not sure if secondary care placements are affected.


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Boris + COVID-19 https://t.co/Zbl8uPZ6ZL


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RT @Cartoon4sale: Steve Bell on #coronavirus #BorisJohnson #COVID19 . Now wash your hands, please. - political cartoon gallery in London https://t.co/dePcTdnXF6 https://t.co/6lK6gCcvYP


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Spot the outlier. Who knows if it is right or wrong, but this is the brexit attitude clearly in action https://t.co/eR0m8dngi9


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Very good read but worrying. https://t.co/8ZxVwFc4Ye


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Prof. Colin Cooper is discussing much of our work in a public lecture in London on 14th May. "Prostate cancer, maths and artificial intelligence". Sign up, it is bound to be an entertaining one. https://t.co/uP1g48OM0U


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Funded mainly by @MovemberUK and The Andy Ripley Memorial Fund.


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RT @UEAResearch: Unnecessary #prostatecancer biopsies could be reduced by 60% thanks to a new urine test being developed at #UEA @UeaMed in collaboration with @NNUH funded by @MovemberUK https://t.co/S3OWwMJgbD https://t.co/lQ2au5ELYd


from Twitter https://twitter.com/danbrewer

Development of a multivariable risk model integrating urinary cell DNA methylation & cell-free RNA data for the detection of significant prostate cancer

New paper out today in "The Prostate"

"Development of a multivariable risk model integrating urinary cell DNA methylation & cell-free RNA data for the detection of significant prostate cancer"

This carries on from the work last year on a urine test called ‘PUR’ (Prostate Urine Risk) which diagnoses aggressive prostate cancer and predicts whether patients will require treatment up to five years earlier than standard clinical methods.

This latest research combines information from two different levels of biological data in urine (methylation and gene expression) and shows the possibilities of further improves in a urine tests use for diagnosis.

What I really like about this one is the robust machine learning techniques we've used and the alignment to the TRIPOD guidelines.

Great work led by my PhD student Shea O'Connell.

Funded mainly by Movember and The Andy Ripley Memorial Fund.

https://doi.org/10.1002/pros.23968

Press:
Urine test could help reduce unnecessary prostate cancer biopsies
Outlet: MailOnline Date: 10/03/2020 00:08
Click to open
Unnecessary prostate cancer biopsies could be reduced by 60 per cent thanks to new research from the University of East Anglia. Lead author Shea Connell and senior author Dr Dan Brewer (both MED) quoted.
AND
I'm still alive thanks to the quick thinking of my mate Sir Tom
Outlet: Daily Express, p.21 Date: 10/03/2020 00:00
AND
Progress on urine test for prostate cancer
Outlet: The Guardian, p.16 Date: 10/03/2020 00:00
AND
Urine test could help reduce unnecessary prostate cancer biopsies
Outlet: ITV (Online) Date: 10/03/2020 11:08
Click to open
AND
UEA scientists in prostate cancer breakthrough
Outlet: Eastern Daily Press (EDP), p.22 Date: 19/03/2020 00:00

+ 198 more


RT @richardneher: Very useful comparison of case fatality ratio by @jbloom_lab! #COVID19 is very dangerous for the elderly! https://t.co/DDm8j3k2Bk https://t.co/tIH0SmqljP


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RT @Dr2NisreenAlwan: Are you young? Are you healthy? Not bothered if you get #COVID2019? Good for you, but DON’T be a spreader! Avoidable deaths *will* happen if health systems can’t cope. Do your bit to #FlattenTheCurve https://t.co/YRATF0mxMP


from Twitter https://twitter.com/danbrewer

Competition funding available for a PhD applying machine learning techniques to Next Generation Sequencing Big Data to improve the prediction of prostate cancer patient outcome. Join us. Stipend and UK/EU fees available. Closing date: 17/04/20 https://t.co/hCRNjxB0jC #phdtalk https://t.co/t7prACEwGA


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RT @dlglsh: Parents: panic buying tissues and soap. Children: https://t.co/Bvr7PHNhHY


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RT @DrDanielSwan: Introverts unite. XKCD on point again. https://t.co/9RIXkPiDrD


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COVID-19 map. This has a really nice animation of the spread over time. https://t.co/1L74PuvQvJ https://t.co/5xY85tgiM5


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Application deadline tomorrow! We are looking for a senior postdoc to work with us on prostate cancer genomics in Norwich, UK. https://t.co/0hoHvsoxU3. @UEAResearch #postdoc #cancer #prostatecancer #genomics #ngs https://t.co/pZceWk2neT


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RT @CNSPE: Great afternoon of netball for some of the Year 7 and 8 girls to apply thier training and skills into a friendly but competitive game against @CAN_Academy. Well played everyone! #netball #thisgirlcan #schoolsport https://t.co/FOby4qSaEZ


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RT @pathogenomenick: "Panic and hysteria are not appropriate. This is a disease that is in the cases and their close contacts. It’s not a hidden enemy lurking behind bushes. Get organized, get educated, and get working." https://t.co/L6ISj46WQM


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Really happy to be starting this project with Dan Woodcock and David Wedge from Oxford University. Thanks @ThePCRC for the support. https://t.co/Bn15i899CX


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Closing date soon. Become a member of an exciting international collaboration researching ways to benefit prostate cancer patients through the analysis of next generation sequencing data combined with high quality clinical and histopathology information. https://t.co/0hoHvsoxU3 https://t.co/0EPBpzefyY


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