The landscape of viral associations in human cancers

A new paper from the PCAWG pathogens group (that we are a part of) is out today in Nature Genetics: 'The landscape of viral associations in human cancers'. Plenty of really interesting insights in there. We discovered traces of 23 different virus types in 356 cancer patients, with 13 percent of the samples having evidence of the presence of viruses. When analysing the whole cancer genome, we discovered traces of viruses in considerably more tumours than in earlier studies that were based on investigating the RNA only. We also further identified some of the mechanisms that viruses use to trigger changes in the DNA of cancer cells. This is the first time that a systematic study of the majority of cancer types for viruses has been made. It is important as unveiling new links between infection and cancer types has the potential to provide actionable opportunities, for example HPV vaccines, which could reduce the global impact of cancer. This is part of the hashtagPanCancer suite of papers.

Finally, here is a layman's article that I wrote for The Conversation.


Comments

Popular posts from this blog

A census of amplified and overexpressed human cancer genes : Nature Reviews Cancer

RT @jburnmurdoch: Most useful thread I’ve read on the dynamics of Covid transmission. By an expert, and packed full of links to evidence. Indoor spaces and or prolonged face-to-face contact account for large majority of Covid transmission. Walking past someone in street/park much lower risk. https://t.co/fnMrDjAxfq

GMail now with IMAP