Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

I've just noticed that the final version of a manuscript based on work by one of my ex-PhD students while under my supervision has finally been published. This is an interesting look at the mechanisms of gene loss (and gain) in prostate cancers. The main mechanism in cancer is a two-hit method where one allele is knocked out by one mutation (substitution, indel, breakpoint, or copy number deletion) and the other allele by a different mutation. In prostate cancer this work hints that this might not be the case for the majority of drivers.

This one was a lot of work but we got there in the end.
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007001

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