Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in...

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

This bit of work has been my main focus for a long time and it is really great that it has finally been published in Nature Genetics. This study, for the first time, has sequenced the whole genetic sequences of multiple samples from the prostate, both from tumours and apparently normal tissue. Surprisingly there were a large number of abnormal genetic changes found in the normal prostate tissue, suggesting that the prostate as a whole is a hot bed of genetic instability and is primed and ready for tumours to develop. This gives us important clues to how prostate cancer develops and has potential consequences to how it is treated.
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3221.html

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