Monday, January 04, 2010

A census of amplified and overexpressed human cancer genes : Nature Reviews Cancer

This paper, that I am an author on, was released on 24th December 2009: "Integrated genome-wide screens of DNA copy number and gene expression in human cancers have accelerated the rate of discovery of amplified and overexpressed genes. However, the biological importance of most of the genes identified in such studies remains unclear. In this Analysis, we propose a weight-of-evidence based classification system for identifying individual genes in amplified regions that are selected for during tumour development. In a census of the published literature we have identified 77 genes for which there is good evidence of involvement in the development of human cancer."

I spent a huge amount of time on this one but I am still pretty low on the author pecking order. This is for a super high impact journal, "Nature Reviews Cancer" which has a 2008 ISI Impact Factor of 30.762.

Also check out the associated website which I put together just before Christmas. Hopefully, this work will get further funding and get regularly updated.